Familial keratoacanthoma is a rare skin condition that is inherited in an autosomal dominant pattern. It is characterized by the development of multiple keratoacanthomas, which are benign tumors that appear as dome-shaped, red-brown bumps on the skin. These bumps can range in size from a few millimeters to several centimeters in diameter. They typically appear on the face, neck, and upper trunk, but can also occur on other parts of the body. Treatment typically involves surgical removal of the tumors.

The most common symptom of familial keratoacanthoma is the development of multiple, small, dome-shaped, red-brown bumps on the skin. These bumps may be itchy or painful and may grow rapidly over a period of weeks. They may also be accompanied by swelling, crusting, and scaling of the skin. In some cases, the bumps may become ulcerated or infected. Other symptoms may include fatigue, fever, and joint pain.

The exact cause of familial keratoacanthoma is unknown. However, it is believed to be related to genetic factors, as it is more common in families with a history of the condition. It is also associated with certain genetic syndromes, such as Muir-Torre syndrome, which is caused by a mutation in the MLH1 gene.

Treatment for familial keratoacanthoma typically involves surgical removal of the affected area. This may be done with a scalpel, laser, or cryotherapy. In some cases, topical medications such as retinoids or imiquimod may be used to reduce the size of the lesion. In more severe cases, radiation therapy may be used.

1. Family history of keratoacanthoma
2. Fair skin
3. Exposure to ultraviolet radiation
4. Immunosuppression
5. Chronic inflammation
6. Certain genetic mutations
7. Certain medications, such as isotretinoin

At this time, there is no known cure for familial keratoacanthoma. Treatment typically involves surgical removal of the affected area, and medications such as topical retinoids, topical corticosteroids, and oral retinoids may be used to reduce the size of the lesion and prevent recurrence.