Familial isolated trichomegaly is a rare genetic disorder characterized by excessive hair growth on the face, scalp, and body. It is caused by a mutation in the gene responsible for the production of the enzyme 5-alpha reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). People with this disorder typically have thick, dark, and coarse hair on their face, scalp, and body. The hair growth is usually symmetrical and can be present at birth or develop during childhood.

The main symptom of Familial isolated trichomegaly is an excessive growth of hair on the face, scalp, and body. This excessive hair growth is usually symmetrical and can be seen in both men and women. Other symptoms may include:

-Thickening of the eyebrows

-Thickening of the eyelashes

-Thickening of the hair on the arms and legs

-Excessive body hair

-Darkening of the skin in areas of excessive hair growth

-Itching or Irritation in areas of excessive hair growth

-Enlarged pores in areas of excessive hair growth

-Acne or other skin problems in areas of excessive hair growth

Familial isolated trichomegaly is a rare genetic disorder caused by mutations in the TGM3 gene. This gene is responsible for producing an enzyme called transglutaminase 3, which is involved in the formation of the hair shaft. Mutations in this gene can lead to an abnormal accumulation of keratin, the protein that makes up the hair shaft, resulting in abnormally long and thick hairs. Other causes of familial isolated trichomegaly include environmental factors, such as exposure to certain chemicals, and certain medications.

The treatment for Familial isolated trichomegaly depends on the severity of the condition. In mild cases, no treatment may be necessary. In more severe cases, treatment may include topical medications such as minoxidil, oral medications such as finasteride, and laser treatments. In some cases, surgery may be necessary to remove the excess hair.

The exact cause of familial isolated trichomegaly is unknown, but there are several risk factors that may increase the likelihood of developing the condition. These include:

• Family history: Having a family member with familial isolated trichomegaly increases the risk of developing the condition.

• Age: The condition is more common in older individuals.

• Gender: Women are more likely to develop familial isolated trichomegaly than men.

• Ethnicity: People of Asian descent are more likely to develop the condition than those of other ethnicities.

• Sun exposure: Excessive sun exposure may increase the risk of developing the condition.

At this time, there is no known cure for Familial Isolated Trichomegaly (FIT). However, there are medications that can help manage the symptoms of FIT. These medications include topical steroids, oral antihistamines, and topical calcineurin inhibitors. Additionally, laser treatments may be used to reduce the size of the trichomes.