Familial episodic pain syndrome with predominantly upper body involvement (FEPPUB) is a rare genetic disorder characterized by recurrent episodes of severe pain in the upper body, including the chest, neck, shoulders, and arms. The episodes typically last for several hours and can be accompanied by nausea, vomiting, and lightheadedness. The episodes can occur spontaneously or be triggered by physical activity or stress. There is no known cure for FEPPUB, but medications and lifestyle modifications can help manage symptoms.

The symptoms of Familial episodic Pain syndrome with predominantly upper body involvement include:

-Recurrent episodes of severe Pain in the chest, neck, shoulders, and/or arms
-Pain episodes lasting from minutes to hours
-Pain episodes occurring at least once a month
-Pain episodes that are not associated with any other medical condition
-Pain episodes that are not relieved by medications
-Pain episodes that are not triggered by any particular activity or event
-Pain episodes that are not associated with any particular time of day or night
-Pain episodes that are not associated with any particular season or weather
-Pain episodes that are not associated with any particular food or drink
-Pain episodes that are not associated with any particular emotional state

The exact cause of Familial episodic pain syndrome with predominantly upper body involvement is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Some research suggests that mutations in certain genes may be involved in the development of this condition. Additionally, certain environmental triggers, such as stress, may also play a role in triggering episodes of pain.

1. Pain medications: Over-the-counter pain medications such as ibuprofen, acetaminophen, and naproxen can help reduce pain and inflammation.

2. Antidepressants: Tricyclic antidepressants such as amitriptyline and nortriptyline can help reduce pain and improve sleep.

3. Anticonvulsants: Medications such as gabapentin and pregabalin can help reduce pain and improve sleep.

4. Physical therapy: Physical therapy can help improve strength, flexibility, and range of motion.

5. Cognitive behavioral therapy: This type of therapy can help reduce stress and anxiety, which can help reduce pain.

6. Relaxation techniques: Relaxation techniques such as deep breathing, progressive muscle relaxation, and guided imagery can help reduce stress and improve sleep

1. Family history of episodic pain syndrome
2. Age of onset before age 20
3. Pain episodes lasting from minutes to hours
4. Pain episodes occurring at least once a month
5. Pain episodes involving the upper body, including the chest, neck, and shoulders
6. Pain episodes that are not associated with any other medical condition
7. Pain episodes that are not relieved by medications or other treatments
8. Anxiety or depression
9. Stressful life events
10. Poor sleep quality

There is no known cure for Familial episodic pain syndrome with predominantly upper body involvement. However, medications such as non-steroidal anti-inflammatory drugs (NSAIDs), tricyclic antidepressants, anticonvulsants, and muscle relaxants may be used to help manage the symptoms. Additionally, lifestyle modifications such as stress management, physical therapy, and relaxation techniques may be beneficial.