Familial calcium pyrophosphate deposition (FCPD) is a rare inherited disorder characterized by the accumulation of calcium pyrophosphate crystals in the joints and other tissues. It is caused by mutations in the ANKH gene, which is responsible for the production of an enzyme involved in the metabolism of pyrophosphate. Symptoms of FCPD include joint pain, swelling, and stiffness, as well as the formation of calcium deposits in the cartilage and other tissues. Treatment typically involves medications to reduce inflammation and pain, as well as physical therapy to maintain joint mobility.

The most common symptoms of Familial calcium pyrophosphate deposition (FCPD) are joint pain, swelling, and stiffness. Other symptoms may include:

-Tenderness in the affected joints

-Redness and warmth in the affected joints

-Decreased range of motion in the affected joints
-Difficulty walking or performing daily activities
-Fatigue
-Fever
-Weight loss
-Depression
-Anemia
-Kidney stones

The exact cause of familial calcium pyrophosphate deposition (CPPD) is unknown. However, it is believed to be related to genetic mutations that affect the metabolism of calcium and pyrophosphate. Other possible causes include an imbalance of calcium and pyrophosphate in the body, an overproduction of pyrophosphate, and an increased sensitivity to pyrophosphate.

1. Non-steroidal anti-inflammatory drugs (NSAIDs) to reduce inflammation and pain.

2. Corticosteroids to reduce inflammation and pain.

3. Intra-articular injections of hyaluronic acid to lubricate the joint and reduce pain.

4. Physical therapy to improve joint mobility and strength.

5. Surgery to remove calcium deposits from the joint.

6. Dietary changes to reduce the amount of calcium in the diet.

7. Supplements to reduce the amount of calcium in the body.

1. Age: Familial calcium pyrophosphate deposition (CPPD) is more common in people over the age of 40.

2. Genetics: Familial CPPD is caused by a genetic mutation that is passed down from parent to child.

3. Gender: Men are more likely to develop Familial CPPD than women.

4. Certain medical conditions: People with certain medical conditions, such as gout, rheumatoid arthritis, and hemochromatosis, are at an increased risk of developing Familial CPPD.

5. Certain medications: Certain medications, such as diuretics and corticosteroids, can increase the risk of Familial CPPD.

There is no cure for Familial calcium pyrophosphate deposition (FCPD). However, medications such as non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine can be used to reduce the symptoms of FCPD. In some cases, corticosteroids may be prescribed to reduce inflammation. In severe cases, surgery may be necessary to remove the deposits of calcium pyrophosphate.