About Familial advanced sleep-phase syndrome

What is Familial advanced sleep-phase syndrome?

Familial advanced sleep-phase syndrome (FASPS) is a rare sleep disorder characterized by a tendency to fall asleep and wake up earlier than normal. People with FASPS typically go to bed and wake up two to four hours earlier than the average person. Symptoms usually begin in childhood or adolescence and can persist into adulthood. FASPS is caused by a mutation in the gene PER3, which is involved in regulating the body's circadian rhythm. Treatment typically involves light therapy, melatonin, and lifestyle changes.

What are the symptoms of Familial advanced sleep-phase syndrome?

The main symptom of Familial advanced sleep-phase syndrome (FASPS) is a tendency to fall asleep and wake up earlier than most people. People with FASPS may fall asleep as early as 6 or 7 pm and wake up as early as 2 or 3 am. Other symptoms may include:

- Difficulty staying awake during the day
- Difficulty concentrating
- Irritability
- Fatigue
- Difficulty sleeping at night
- Waking up feeling unrested
- Difficulty falling asleep at a later time

What are the causes of Familial advanced sleep-phase syndrome?

The exact cause of Familial advanced sleep-phase syndrome (FASPS) is unknown. However, it is believed to be caused by a mutation in the gene responsible for regulating the body’s circadian rhythm. This gene, called hPer2, is responsible for controlling the body’s internal clock and helps to regulate when we feel sleepy and when we feel alert. It is thought that a mutation in this gene can cause the body’s internal clock to be shifted earlier, resulting in earlier sleep and wake times.

What are the treatments for Familial advanced sleep-phase syndrome?

1. Light therapy: Light therapy is the most common treatment for Familial advanced sleep-phase syndrome. It involves exposing yourself to bright light in the morning and avoiding bright light in the evening. This helps to reset your body’s internal clock and can help you fall asleep and wake up at more normal times.

2. Melatonin: Melatonin is a hormone that helps regulate your sleep-wake cycle. Taking melatonin supplements in the evening can help you fall asleep earlier and wake up earlier.

3. Stimulus control: Stimulus control is a behavioral therapy that helps you associate your bed with sleep. It involves avoiding activities in bed other than sleep and going to bed only when you’re sleepy.

4. Sleep hygiene: Sleep hygiene involves establishing healthy sleep habits, such as avoiding caffeine and alcohol before bed, avoiding screens

What are the risk factors for Familial advanced sleep-phase syndrome?

1. Family history: Familial advanced sleep-phase syndrome (FASPS) is an inherited disorder, so having a family history of the condition increases the risk of developing it.

2. Age: FASPS is more common in older adults, so the risk increases with age.

3. Gender: FASPS is more common in women than men.

4. Sleep deprivation: Not getting enough sleep can increase the risk of developing FASPS.

5. Stress: Stress can disrupt the body’s natural sleep-wake cycle, which can increase the risk of developing FASPS.

Is there a cure/medications for Familial advanced sleep-phase syndrome?

Yes, there are medications and treatments available for Familial advanced sleep-phase syndrome. These include light therapy, melatonin, and chronotherapy. Additionally, lifestyle changes such as avoiding caffeine and alcohol, exercising regularly, and maintaining a consistent sleep schedule can help manage the symptoms of Familial advanced sleep-phase syndrome.