EPHB4-related lymphatic-related hydrops fetalis is a rare genetic disorder caused by mutations in the EPHB4 gene. It is characterized by abnormal development of the lymphatic system in the fetus, leading to an accumulation of fluid in the body cavities and tissues. This can cause severe swelling, breathing difficulties, and heart failure. Treatment typically involves draining the excess fluid and providing supportive care.

The symptoms of EPHB4-related lymphatic-related hydrops fetalis include:

-Enlarged abdomen
-Enlarged liver and spleen
-Fluid accumulation in the abdomen, chest, and/or limbs
-Low levels of albumin in the blood
-Low levels of protein in the blood
-Low levels of red blood cells
-Low levels of white blood cells
-Heart defects
-Respiratory distress
-Developmental delays
-Feeding difficulties
-Growth retardation
-Jaundice
-Hemorrhage
-Anemia
-Hypoglycemia
-Hypocalcemia
-Hyponatremia

EPHB4-related lymphatic-related hydrops fetalis is caused by mutations in the EPHB4 gene. This gene is responsible for the production of a protein that is essential for the development of the lymphatic system. Mutations in this gene can lead to abnormal development of the lymphatic system, resulting in the accumulation of fluid in the fetus. This can lead to hydrops fetalis, a condition characterized by swelling of the fetus due to the accumulation of fluid.

The primary treatment for EPHB4-related lymphatic-related hydrops fetalis is prenatal intervention. This includes the use of antenatal steroids to reduce the risk of preterm delivery, as well as the use of fetal blood transfusions to reduce the risk of fetal anemia. In some cases, postnatal surgery may be necessary to correct the underlying defect. In addition, supportive care such as respiratory support, nutrition, and hydration may be necessary.

1. Maternal consanguinity
2. Maternal age over 35
3. Maternal history of recurrent miscarriages
4. Maternal history of preterm delivery
5. Maternal history of stillbirth
6. Maternal history of hydrops fetalis
7. Maternal history of EPHB4-related lymphatic-related hydrops fetalis
8. Maternal history of other genetic disorders
9. Maternal history of exposure to certain medications or toxins
10. Maternal history of infection during pregnancy
11. Family history of EPHB4-related lymphatic-related hydrops fetalis
12. Abnormal ultrasound findings during pregnancy

At this time, there is no known cure or medication for EPHB4-related lymphatic-related hydrops fetalis. Treatment is focused on supportive care, such as providing nutrition and fluids, monitoring the baby's condition, and providing respiratory support if needed. In some cases, surgery may be recommended to help improve the baby's condition.