Dubin Johnson Syndrome is a rare inherited disorder that affects the liver. It is caused by a mutation in the gene responsible for the production of the enzyme uridine diphosphate glucuronosyltransferase (UGT1A1). Symptoms of the disorder include jaundice, dark urine, and an enlarged liver. In some cases, the disorder can lead to liver failure. Treatment typically involves medications to reduce the symptoms and liver transplantation in severe cases.

The most common symptoms of Dubin Johnson Syndrome include jaundice, dark urine, light-colored stools, abdominal pain, and an enlarged liver. Other symptoms may include fatigue, nausea, vomiting, fever, and weight loss. In some cases, patients may also experience itching, joint pain, and an enlarged spleen.

Dubin Johnson Syndrome is a rare inherited disorder caused by a mutation in the ABCB11 gene. This gene is responsible for producing a protein that helps transport bile acids from the liver to the small intestine. Mutations in this gene can lead to an accumulation of bile acids in the liver, resulting in Dubin Johnson Syndrome.

The treatment for Dubin Johnson Syndrome is primarily supportive and symptomatic. This includes dietary modifications, such as avoiding foods high in fat and cholesterol, as well as medications to reduce symptoms. Medications may include ursodeoxycholic acid, cholestyramine, and rifampin. Liver transplantation may be considered in severe cases.

The exact cause of Dubin Johnson Syndrome is unknown, but it is thought to be an inherited disorder. Risk factors for Dubin Johnson Syndrome include having a family history of the disorder, being of certain ethnic backgrounds, and having certain genetic mutations.

There is no cure for Dubin Johnson Syndrome, but medications can be used to manage the symptoms. These medications may include cholestyramine, ursodeoxycholic acid, and rifampin. Additionally, lifestyle changes such as a low-fat diet and regular exercise may help to reduce symptoms.