Distal myopathy, Tateyama type is a rare form of muscular dystrophy that affects the muscles in the arms and legs. It is characterized by slowly progressive muscle weakness and wasting, primarily affecting the distal muscles of the arms and legs. It is caused by a mutation in the DYSF gene, which is responsible for producing a protein called dysferlin. Symptoms typically begin in the teenage years and worsen over time. Treatment is supportive and may include physical therapy, occupational therapy, and assistive devices.

The symptoms of Distal myopathy, Tateyama type, include:

-Muscle Weakness and wasting in the distal muscles of the arms and legs
-Difficulty walking and climbing stairs
-Difficulty with fine motor skills such as writing and buttoning
-Muscle cramps and stiffness
-Muscle pain
-Decreased reflexes
-Foot drop
-Difficulty with balance and coordination
-Fatigue

Distal myopathy, Tateyama type is caused by a mutation in the DYSF gene. This gene is responsible for producing a protein called dysferlin, which is involved in muscle repair and maintenance. Mutations in this gene can lead to a decrease in the amount of dysferlin produced, resulting in the development of Distal myopathy, Tateyama type.

The treatments for Distal myopathy, Tateyama type, are mainly supportive and symptomatic. Treatment may include physical therapy, occupational therapy, speech therapy, orthopedic devices, and assistive devices. Medications may also be prescribed to help manage muscle weakness, pain, and fatigue. In some cases, surgery may be recommended to help improve mobility and function.

1. Autosomal recessive inheritance
2. Mutations in the VCP gene
3. Age of onset typically between 5 and 15 years
4. Proximal muscle weakness
5. Distal muscle weakness
6. Muscle wasting
7. Muscle cramps
8. Muscle stiffness
9. Difficulty walking
10. Difficulty climbing stairs
11. Difficulty rising from a seated position
12. Difficulty with fine motor skills
13. Impaired balance
14. Impaired coordination
15. Impaired speech
16. Impaired swallowing
17. Impaired vision
18. Impaired hearing
19. Cognitive impairment
20. Seizures
21. Cardiac arrhythmias
22. Respiratory problems
23. Elevated levels of creatine kinase in the blood

At this time, there is no known cure for Distal myopathy, Tateyama type. However, there are medications that can help manage the symptoms of the condition. These medications include corticosteroids, immunosuppressants, and physical therapy. Additionally, lifestyle modifications such as avoiding strenuous activities and maintaining a healthy diet can help reduce the symptoms of the condition.