Distal arthrogryposis type 10 is a rare genetic disorder characterized by joint contractures and muscle weakness in the hands, feet, and lower legs. It is caused by mutations in the MYH3 gene, which is responsible for the production of a protein called myosin. Symptoms of this disorder can include limited range of motion in the hands and feet, clubfoot, and scoliosis.

The symptoms of Distal arthrogryposis type 10 vary from person to person, but may include:

-Joint contractures of the hands, feet, and/or ankles
-Flexion contractures of the elbows, wrists, and/or fingers
-Clubfoot
-Hip dislocation
-Scoliosis
-Kyphosis
-Abnormal facial features
-Feeding difficulties
-Developmental delay
-Intellectual disability
-Seizures
-Hearing loss
-Vision problems
-Heart defects
-Gastrointestinal problems

Distal arthrogryposis type 10 is caused by a genetic mutation in the MYH3 gene. This gene is responsible for the production of a protein called myosin, which is essential for the development of muscles. Mutations in this gene can lead to the development of abnormal muscle fibers, which can cause the symptoms associated with distal arthrogryposis type 10.

1. Physical therapy: Physical therapy is the mainstay of treatment for distal arthrogryposis type 10. Physical therapy can help improve range of motion, strength, and coordination.

2. Surgery: Surgery may be recommended to correct joint deformities or to release tight muscles.

3. Splinting: Splinting can help maintain joint position and prevent contractures.

4. Occupational therapy: Occupational therapy can help improve fine motor skills and activities of daily living.

5. Orthotics: Orthotics can help improve posture and gait.

6. Medications: Medications such as muscle relaxants and pain medications may be prescribed to help manage symptoms.

1. Genetic mutations
2. Maternal diabetes
3. Maternal smoking
4. Maternal alcohol consumption
5. Maternal drug use
6. Maternal infections
7. Advanced maternal age
8. Low birth weight
9. Premature birth
10. Exposure to certain medications during pregnancy

At this time, there is no known cure for Distal arthrogryposis type 10. However, there are medications and treatments available to help manage the symptoms. These include physical therapy, occupational therapy, braces, splints, and medications to help reduce pain and muscle spasms.