Diffuse large B-cell lymphoma with chronic inflammation (DLBCL-CI) is a rare type of non-Hodgkin lymphoma (NHL) that is characterized by the presence of both diffuse large B-cell lymphoma and chronic inflammation. It is a type of aggressive NHL that is associated with a poor prognosis. The chronic inflammation is thought to be caused by an underlying autoimmune disorder, such as rheumatoid arthritis or systemic lupus erythematosus. Treatment typically involves chemotherapy and/or radiation therapy.

Common symptoms of Diffuse large B-cell lymphoma with chronic Inflammation include:

-Fever
-Night sweats
-Unexplained weight loss
-Loss of appetite
-Fatigue
-Pain or swelling in the lymph nodes
-Abdominal Pain or swelling
-Coughing
-Shortness of breath
-Itching
-Skin rash or changes in skin color
-Bone pain
-Headaches
-Blurred vision
-Confusion or changes in mental status

The exact cause of Diffuse large B-cell lymphoma with chronic inflammation is unknown. However, some risk factors have been identified, including:

-Exposure to certain chemicals, such as benzene, pesticides, and herbicides
-Exposure to radiation
-Infection with certain viruses, such as Epstein-Barr virus (EBV)
-A weakened immune system
-Autoimmune diseases, such as rheumatoid arthritis
-Family history of lymphoma
-Certain genetic mutations, such as those in the BCL2 gene

1. Chemotherapy: Chemotherapy is the most common treatment for diffuse large B-cell lymphoma with chronic inflammation. It involves using drugs to kill cancer cells.

2. Radiation therapy: Radiation therapy uses high-energy beams to kill cancer cells. It may be used in combination with chemotherapy.

3. Targeted therapy: Targeted therapy uses drugs to target specific molecules in cancer cells. It may be used in combination with chemotherapy.

4. Immunotherapy: Immunotherapy uses drugs to boost the body’s immune system to fight cancer cells. It may be used in combination with chemotherapy.

5. Stem cell transplant: A stem cell transplant may be used to replace damaged or destroyed cells with healthy ones. It may be used in combination with chemotherapy.

1. Age: Diffuse large B-cell lymphoma with chronic inflammation is more common in older adults.

2. Gender: Men are more likely to develop this type of lymphoma than women.

3. Immunosuppression: People with weakened immune systems, such as those with HIV/AIDS or those taking immunosuppressive medications, are at an increased risk.

4. Exposure to certain chemicals: Exposure to certain chemicals, such as benzene, may increase the risk of developing this type of lymphoma.

5. Autoimmune diseases: People with autoimmune diseases, such as rheumatoid arthritis, are at an increased risk.

6. Family history: Having a family history of lymphoma may increase the risk.

Yes, there are treatments available for Diffuse large B-cell lymphoma with chronic inflammation. Treatment options may include chemotherapy, radiation therapy, targeted therapy, immunotherapy, stem cell transplant, and/or surgery. Your doctor will be able to discuss the best treatment plan for you based on your individual situation.