Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder is a rare inherited disorder caused by a deficiency of the enzyme cytosolic phospholipase-A2 alpha (cPLA2α). This enzyme is involved in the production of arachidonic acid, a fatty acid that is important for the production of certain hormones and other molecules involved in inflammation and blood clotting. People with this disorder have a decreased ability to produce arachidonic acid, which can lead to a variety of bleeding problems, including prolonged bleeding after surgery or injury, easy bruising, and excessive bleeding during menstruation.

The symptoms of Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder include:

-Easy bruising
-Excessive bleeding from cuts or injuries
-Nosebleeds
-Heavy menstrual bleeding
-Bleeding in the gastrointestinal tract
-Bleeding in the brain
-Blood in the urine or stool
-Joint Pain and swelling due to bleeding into the joint spaces
-Anemia due to chronic blood loss

Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder is caused by mutations in the PLA2G6 gene. This gene provides instructions for making an enzyme called cytosolic phospholipase A2 alpha (cPLA2α). This enzyme is involved in the production of molecules called prostaglandins and leukotrienes, which are involved in inflammation and other processes in the body. Mutations in the PLA2G6 gene reduce or eliminate the activity of cPLA2α, leading to a deficiency of this enzyme. This deficiency can cause a bleeding disorder characterized by prolonged bleeding after injury or surgery, easy bruising, and nosebleeds.

1. Desmopressin (DDAVP): Desmopressin is a synthetic form of the hormone vasopressin, which helps to increase the levels of clotting factors in the blood. It is used to treat mild to moderate bleeding episodes in people with Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder.

2. Tranexamic acid: Tranexamic acid is an antifibrinolytic drug that helps to reduce the breakdown of clots in the blood. It is used to treat moderate to severe bleeding episodes in people with Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder.

3. Platelet transfusions: Platelet transfusions are used to replace missing or damaged platelets in the blood. Platelet transfusions can help to reduce the risk

1. Family history of the disorder
2. Premature birth
3. Low birth weight
4. Low platelet count
5. Low levels of clotting factors
6. Exposure to certain medications or toxins
7. Infections
8. Surgery or trauma
9. Vitamin K deficiency
10. Liver disease

At this time, there is no known cure for Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder. However, there are medications that can be used to help manage the symptoms of the disorder. These medications include antifibrinolytic agents such as tranexamic acid, desmopressin, and factor VIII concentrates. Additionally, platelet transfusions may be used to help control bleeding episodes.