Congenital limbs-face contractures-hypotonia-developmental delay syndrome (CLFHDD) is a rare genetic disorder characterized by the presence of contractures of the limbs and face, hypotonia (low muscle tone), and developmental delay. Affected individuals may also have other features, such as seizures, intellectual disability, and vision and hearing problems. The exact cause of CLFHDD is unknown, but it is believed to be caused by a genetic mutation. Treatment is based on the individual's symptoms and may include physical therapy, occupational therapy, speech therapy, and medications.

The symptoms of Congenital Limbs-Face Contractures-Hypotonia-Developmental Delay Syndrome (CLFCHD) include:

- Limb contractures, including clubfoot, hip dislocation, and/or joint stiffness
- Facial contractures, including cleft lip/palate, micrognathia, and/or microcephaly
- Hypotonia (low muscle tone)
- Developmental delay, including delays in motor, cognitive, and/or language development
- Feeding difficulties
- Seizures
- Abnormalities of the eyes, ears, and/or heart
- Abnormalities of the urinary tract and/or genitalia
- Abnormalities of the skeleton, including Scoliosis and/or rib anomalies

The exact cause of Congenital Limbs-Face Contractures-Hypotonia-Developmental Delay Syndrome (CLFCHD) is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Possible causes include chromosomal abnormalities, genetic mutations, and exposure to certain environmental toxins.

Treatment for Congenital Limbs-Face Contractures-Hypotonia-Developmental Delay Syndrome (CLFCHDDS) will depend on the individual needs of the patient. Treatment may include physical therapy, occupational therapy, speech therapy, and/or medications to help with muscle tone and coordination. Surgery may be necessary to correct any physical deformities. Additionally, behavioral therapy may be recommended to help the patient learn new skills and cope with any emotional issues. Finally, genetic counseling may be recommended to help the family understand the condition and any potential risks associated with it.

1. Maternal diabetes
2. Maternal alcohol or drug use
3. Maternal infection
4. Maternal exposure to certain medications
5. Maternal age
6. Genetic factors
7. Low birth weight
8. Premature birth
9. Exposure to certain environmental toxins
10. Exposure to radiation

Unfortunately, there is no cure for Congenital Limbs-Face Contractures-Hypotonia-Developmental Delay Syndrome. However, there are medications and therapies that can help manage the symptoms. These include physical therapy, occupational therapy, speech therapy, medications to help with muscle tone, and medications to help with cognitive development. Additionally, surgery may be recommended in some cases to help improve the function of affected limbs.