Combined hamartoma of the retina and retinal pigment epithelium (CHRPE) is a rare, benign tumor of the eye. It is composed of both retinal tissue and retinal pigment epithelium (RPE). CHRPE typically appears as a flat, pigmented lesion in the retina and is usually found in the macula, the area of the retina responsible for central vision. It is usually asymptomatic and does not cause any vision loss. However, it can be associated with other eye conditions, such as age-related macular degeneration, and can lead to vision loss if left untreated. Treatment for CHRPE typically involves laser photocoagulation or cryotherapy.

The symptoms of Combined hamartoma of the retina and retinal pigment epithelium include:

-Decreased vision
-Distorted vision
-Blurred vision
-Floaters
-Flashes of light
-Dark spots in the field of vision
-Loss of peripheral vision
-Night blindness

The exact cause of combined hamartoma of the retina and retinal pigment epithelium (CHRPE) is unknown. It is thought to be a congenital disorder, meaning it is present at birth. It is believed to be caused by a mutation in the genes that control the development of the eye.

The treatment for Combined hamartoma of the retina and retinal pigment epithelium depends on the severity of the condition. In some cases, no treatment is necessary. However, if the condition is causing vision problems, treatment may include laser therapy, photodynamic therapy, or vitrectomy. In some cases, medications such as corticosteroids may be prescribed to reduce inflammation.

1. Genetic predisposition
2. Family history of the condition
3. Premature birth
4. Low birth weight
5. Exposure to certain medications or toxins during pregnancy
6. Exposure to radiation
7. Certain chromosomal abnormalities
8. Certain genetic syndromes, such as tuberous sclerosis complex

At this time, there is no known cure for Combined Hamartoma of the Retina and Retinal Pigment Epithelium (CHRPE). Treatment is typically focused on managing symptoms and preventing further vision loss. This may include medications such as corticosteroids, anti-inflammatory drugs, and laser photocoagulation. In some cases, surgery may be recommended to remove the lesion.