Circumscribed palmoplantar hypokeratosis is a rare skin disorder characterized by thick, scaly patches of skin on the palms of the hands and soles of the feet. It is caused by an abnormal buildup of keratin, a protein found in the outer layer of the skin. Symptoms may include dry, scaly patches of skin, itching, and pain. Treatment typically involves the use of topical medications and moisturizers to reduce the symptoms.

The main symptom of circumscribed palmoplantar hypokeratosis is the presence of thick, yellowish, scaly patches on the palms and soles of the feet. These patches may be itchy and may cause discomfort. Other symptoms may include dryness, cracking, and peeling of the skin on the palms and soles. In some cases, the patches may become inflamed and painful.

Circumscribed palmoplantar hypokeratosis is a rare skin condition that is caused by a genetic mutation. It is believed to be caused by a mutation in the gene that codes for the enzyme transglutaminase-1, which is responsible for the formation of the outer layer of the skin. Other possible causes include environmental factors, such as exposure to certain chemicals, and certain medications.

1. Topical retinoids: Topical retinoids, such as tretinoin, can be used to reduce the thickness of the skin on the palms and soles.

2. Topical corticosteroids: Topical corticosteroids, such as hydrocortisone, can be used to reduce inflammation and itching.

3. Emollients: Emollients, such as petroleum jelly, can be used to soften and moisturize the skin.

4. Phototherapy: Phototherapy, such as narrowband ultraviolet B (UVB) light, can be used to reduce the thickness of the skin.

5. Oral retinoids: Oral retinoids, such as isotretinoin, can be used to reduce the thickness of the skin.

6. Surgery: Surgery may

1. Genetic predisposition
2. Exposure to certain chemicals
3. Certain medical conditions, such as diabetes, psoriasis, and eczema
4. Certain medications, such as anticonvulsants and lithium
5. Exposure to ultraviolet light
6. Certain skin infections, such as tinea pedis (athlete’s foot)

There is no known cure for circumscribed palmoplantar hypokeratosis. Treatment is usually focused on managing the symptoms, which may include topical creams, moisturizers, and emollients to help reduce the dryness and scaling of the skin. In some cases, oral medications such as retinoids or calcipotriene may be prescribed to help reduce the thickening of the skin.