Brachydactyly-preaxial hallux varus syndrome is a rare genetic disorder characterized by shortening of the fingers and toes (brachydactyly) and an inward turning of the big toe (hallux varus). It is caused by a mutation in the HOXD13 gene. Symptoms may include shortening of the fingers and toes, an inward turning of the big toe, and a wide gap between the first and second toes. Other features may include a short stature, a curved spine, and a cleft palate. Treatment may include physical therapy, orthopedic surgery, and genetic counseling.

The main symptom of Brachydactyly-preaxial hallux varus syndrome is a deformity of the big toe, which is bent inward and downward. Other symptoms may include:

- Shortening of the first toe
- Abnormal curvature of the first toe
- Abnormal shape of the first toe
- Abnormal placement of the first toe
- Abnormal joint movement of the first toe
- Abnormal nail growth on the first toe
- Abnormal skin texture on the first toe
- Pain and discomfort in the first toe
- Difficulty walking or standing due to the deformity of the first toe

Brachydactyly-preaxial hallux varus syndrome is a rare genetic disorder caused by a mutation in the HOXD13 gene. This gene is responsible for the development of the hands, feet, and other parts of the body. The mutation in this gene can cause the bones in the hands and feet to be abnormally short and the big toe to be bent inward. There is no known cause for this mutation, but it is believed to be inherited in an autosomal dominant pattern.

1. Surgery: Surgery is the most common treatment for brachydactyly-preaxial hallux varus syndrome. The goal of surgery is to correct the deformity and improve the function of the affected foot. Surgery may involve cutting and repositioning the bones of the foot, as well as releasing the tight tendons and ligaments.

2. Orthotics: Orthotics, such as custom-made shoe inserts, can help to reduce pain and improve the function of the affected foot.

3. Physical Therapy: Physical therapy can help to strengthen the muscles and improve the range of motion of the affected foot.

4. Splinting: Splinting can help to reduce pain and improve the function of the affected foot.

5. Medication: Non-steroidal anti-inflammatory drugs (NSAIDs)

1. Genetic predisposition: Brachydactyly-preaxial hallux varus syndrome is an inherited disorder, meaning it is passed down from parents to their children.

2. Environmental factors: Exposure to certain environmental toxins or radiation may increase the risk of developing this condition.

3. Age: The risk of developing Brachydactyly-preaxial hallux varus syndrome increases with age.

4. Gender: This condition is more common in males than females.

5. Ethnicity: This condition is more common in certain ethnic groups, such as those of African or Asian descent.

At this time, there is no known cure for Brachydactyly-preaxial hallux varus syndrome. However, there are treatments available to help manage the symptoms. These include orthopedic surgery to correct the deformity, physical therapy to improve range of motion, and bracing to help support the foot. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) may also be prescribed to reduce pain and inflammation.