Benign recurrent intrahepatic cholestasis (BRIC) is a rare disorder of the liver that causes episodes of jaundice (yellowing of the skin and eyes) and itching. It is caused by a blockage of bile flow in the liver, which can lead to a buildup of bile acids in the blood. BRIC is a chronic condition, meaning that it can last for months or years. Treatment typically involves medications to reduce itching and to help the liver function better.

The main symptom of Benign recurrent intrahepatic cholestasis (BRIC) is recurrent episodes of intense Itching (pruritus) that can last for days or weeks. Other symptoms may include:

-Jaundice (yellowing of the skin and eyes)
-Dark urine
-Pale stools
-Abdominal pain
-Nausea
-Loss of appetite
-Fatigue
-Weight loss
-Fever

The exact cause of Benign recurrent intrahepatic cholestasis (BRIC) is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Genetic factors may include mutations in the ABCB4 gene, which is responsible for transporting bile acids out of the liver. Environmental factors may include certain medications, alcohol, and viral infections.

The main treatment for Benign recurrent intrahepatic cholestasis (BRIC) is supportive care. This includes lifestyle modifications such as avoiding alcohol and certain medications, eating a healthy diet, and exercising regularly. Other treatments may include medications to reduce itching, antibiotics to treat infections, and medications to reduce inflammation. In some cases, a liver transplant may be necessary.

The risk factors for Benign recurrent intrahepatic cholestasis (BRIC) include:

1. Female gender
2. Age (most commonly occurs in adults between the ages of 30 and 50)
3. Family history of BRIC
4. Pregnancy
5. Certain medications (such as estrogens, progestins, and anabolic steroids)
6. Liver disease
7. Alcohol use
8. Obesity
9. Gallstones
10. Intrahepatic bile duct obstruction

There is no cure for Benign recurrent intrahepatic cholestasis (BRIC). Treatment focuses on relieving symptoms and preventing complications. Medications that may be used to treat BRIC include ursodeoxycholic acid (UDCA), rifampicin, and cholestyramine. Other treatments may include dietary changes, vitamin supplements, and lifestyle modifications.