Autosomal spastic paraplegia type 72 (SPG72) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SPG72 gene, which is located on chromosome 17. Symptoms usually begin in childhood or adolescence and may include difficulty walking, stiffness in the legs, and muscle weakness. In some cases, the disorder may also cause intellectual disability, seizures, and vision problems. Treatment is symptomatic and may include physical therapy, medications, and assistive devices.

The symptoms of Autosomal spastic paraplegia type 72 (SPG72) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Loss of sensation in the legs
- Urinary and/or bowel incontinence
- Pain in the legs
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal spastic paraplegia type 72 (SPG72) is a rare genetic disorder caused by mutations in the SPG72 gene. Mutations in this gene lead to the production of an abnormal protein, which disrupts the normal functioning of the nervous system. This can lead to a range of symptoms, including muscle weakness, spasticity, and difficulty walking.

Currently, there is no known cure for Autosomal spastic paraplegia type 72. Treatment focuses on managing the symptoms and preventing further complications. Treatment options may include physical therapy, occupational therapy, speech therapy, medications to reduce muscle spasms, braces or orthotics to support weakened muscles, and surgery to correct any deformities. Additionally, lifestyle modifications such as avoiding activities that may cause further injury, maintaining a healthy diet, and getting regular exercise can help to improve overall health and quality of life.

1. Genetic mutation in the SPG72 gene
2. Family history of autosomal spastic paraplegia type 72
3. Age of onset typically between 20 and 40 years old
4. Progressive muscle weakness and spasticity in the lower limbs
5. Difficulty walking, running, and climbing stairs
6. Loss of bladder and bowel control
7. Muscle cramps and spasms
8. Difficulty with fine motor skills
9. Cognitive impairment
10. Speech and language difficulties

At this time, there is no known cure or medications for Autosomal spastic paraplegia type 72. Treatment focuses on managing the symptoms and preventing further complications. This may include physical therapy, occupational therapy, speech therapy, and medications to reduce muscle spasms and pain.