Autosomal recessive spastic paraplegia type 74 (SPG74) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SLC33A1 gene, which is responsible for the production of a protein called acetyl-CoA synthetase. Symptoms typically begin in childhood or adolescence and worsen over time. Affected individuals may experience difficulty walking, balance problems, and muscle spasms. Other symptoms may include bladder and bowel problems, sensory disturbances, and cognitive impairment.

The symptoms of Autosomal recessive spastic paraplegia type 74 (SPG74) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Abnormal gait
- Urinary and/or fecal incontinence
- Muscle spasms
- Pain in the legs
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal recessive spastic paraplegia type 74 (SPG74) is caused by mutations in the SLC33A1 gene. This gene provides instructions for making a protein that is involved in transporting molecules across cell membranes. Mutations in this gene lead to a decrease in the amount of functional SLC33A1 protein, which disrupts the transport of molecules across cell membranes and causes the signs and symptoms of SPG74.

Currently, there is no known cure for Autosomal recessive spastic paraplegia type 74. Treatment focuses on managing the symptoms and preventing further complications. This may include physical therapy, occupational therapy, speech therapy, and medications to reduce muscle spasms and pain. Assistive devices such as wheelchairs, walkers, and braces may also be used to help with mobility. In some cases, surgery may be recommended to help improve mobility.

1. Having a family history of Autosomal recessive spastic paraplegia type 74.
2. Being of Ashkenazi Jewish descent.
3. Having a mutation in the SLC33A1 gene.
4. Being exposed to certain environmental factors.
5. Having a weakened immune system.

At this time, there is no known cure or medications for Autosomal recessive spastic paraplegia type 74. Treatment focuses on managing the symptoms and preventing complications. This may include physical therapy, occupational therapy, speech therapy, orthopedic devices, and medications to reduce spasticity.