Autosomal recessive spastic paraplegia type 62 (SPG62) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SLC33A1 gene, which is responsible for the production of a protein called aspartoacylase. Symptoms usually begin in childhood or adolescence and may include difficulty walking, muscle stiffness, and weakness in the legs. Other symptoms may include bladder and bowel problems, speech difficulties, and cognitive impairment. Treatment is supportive and may include physical therapy, medications, and assistive devices.

The symptoms of Autosomal recessive spastic paraplegia type 62 (SPG62) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Abnormal gait
- Urinary and/or fecal incontinence
- Muscle spasms
- Pain in the legs
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal recessive spastic paraplegia type 62 (SPG62) is caused by mutations in the SLC33A1 gene. This gene provides instructions for making a protein that is involved in transporting molecules into and out of cells. Mutations in this gene lead to a decrease in the amount of functional SLC33A1 protein, which disrupts the transport of molecules into and out of cells and causes the signs and symptoms of SPG62.

1. Physical therapy: Physical therapy can help improve muscle strength, flexibility, and coordination. It can also help reduce spasticity and improve balance and gait.

2. Medications: Medications such as baclofen, diazepam, and tizanidine can help reduce spasticity and improve muscle control.

3. Surgery: Surgery may be recommended to correct any structural abnormalities in the spine or to release tight muscles.

4. Assistive devices: Assistive devices such as walkers, canes, and wheelchairs can help improve mobility.

5. Occupational therapy: Occupational therapy can help improve daily living skills and help with activities of daily living.

6. Speech therapy: Speech therapy can help improve communication skills.

1. Having a family history of Autosomal recessive spastic paraplegia type 62.
2. Being of Ashkenazi Jewish descent.
3. Having a mutation in the SPG62 gene.
4. Being exposed to certain environmental toxins.
5. Having a weakened immune system.

At this time, there is no known cure or medications for Autosomal recessive spastic paraplegia type 62. Treatment focuses on managing the symptoms and preventing complications. This may include physical therapy, occupational therapy, speech therapy, orthopedic devices, and medications to reduce spasticity.