Autosomal recessive spastic paraplegia type 27 (SPG27) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SPG27 gene, which is responsible for producing a protein called paraplegin. Symptoms typically begin in childhood or adolescence and worsen over time. Affected individuals may experience difficulty walking, balance problems, and muscle spasms. There is currently no cure for SPG27, but physical therapy and medications may help manage symptoms.

The symptoms of Autosomal recessive spastic paraplegia type 27 (SPG27) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Abnormal gait
- Urinary and/or fecal incontinence
- Muscle spasms
- Pain in the legs
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal recessive spastic paraplegia type 27 (SPG27) is caused by mutations in the SPG27 gene. This gene provides instructions for making a protein called paraplegin, which is found in the mitochondria of cells. Mutations in the SPG27 gene lead to a decrease in the amount of paraplegin protein, which disrupts the normal function of mitochondria and causes the signs and symptoms of SPG27.

Currently, there is no known cure for Autosomal recessive spastic paraplegia type 27. Treatment focuses on managing the symptoms and preventing further complications. This may include physical therapy, occupational therapy, speech therapy, and medications to help manage muscle spasms and pain. Assistive devices such as wheelchairs, walkers, and braces may also be used to help with mobility.

1. Having a family history of Autosomal recessive spastic paraplegia type 27.
2. Being of Ashkenazi Jewish descent.
3. Having a mutation in the SLC33A1 gene.
4. Being exposed to environmental toxins.
5. Having a weakened immune system.

At this time, there is no known cure or medications for Autosomal recessive spastic paraplegia type 27. Treatment focuses on managing the symptoms and preventing complications. This may include physical therapy, occupational therapy, speech therapy, orthopedic devices, and medications to reduce spasticity.