Autosomal recessive extra-oral halitosis is a rare genetic disorder characterized by an unpleasant odor emanating from the mouth and nose. It is caused by a mutation in the gene responsible for the production of an enzyme called cytochrome P450 2E1 (CYP2E1). This enzyme is responsible for breaking down certain compounds in the body, including alcohol and other toxins. People with this disorder have a reduced ability to break down these compounds, leading to an accumulation of these compounds in the body and the production of an unpleasant odor.

Symptoms of Autosomal recessive extra-oral halitosis include:

-Persistent bad breath
-Dry mouth
-Difficulty swallowing
-Sore throat
-Hoarseness
-Coughing
-Nasal congestion
-Sinus pressure
-Headache
-Fatigue
-Loss of appetite
-Weight loss
-Nausea
-Vomiting
-Diarrhea
-Abdominal pain
-Joint pain
-Muscle pain
-Skin rashes
-Itching
-Depression
-Anxiety

1. Poor oral hygiene
2. Certain genetic disorders, such as cystic fibrosis
3. Certain metabolic disorders, such as phenylketonuria (PKU)
4. Certain endocrine disorders, such as diabetes
5. Certain medications, such as antibiotics
6. Certain foods, such as garlic and onions
7. Certain medical conditions, such as kidney or liver disease
8. Certain dental conditions, such as gum disease or cavities
9. Certain respiratory conditions, such as sinusitis or bronchitis
10. Certain digestive conditions, such as gastroesophageal reflux disease (GERD)

1. Genetic predisposition: Autosomal recessive extra-oral halitosis is caused by a genetic mutation, so those with a family history of the condition are at higher risk.

2. Poor oral hygiene: Poor oral hygiene can lead to an accumulation of bacteria in the mouth, which can contribute to halitosis.

3. Certain medical conditions: Certain medical conditions, such as diabetes, kidney disease, and liver disease, can increase the risk of halitosis.

4. Certain medications: Certain medications, such as antibiotics, can cause dry mouth, which can lead to halitosis.

5. Smoking: Smoking can contribute to halitosis by causing dry mouth and increasing the amount of bacteria in the mouth.

There is no known cure for autosomal recessive extra-oral halitosis. However, there are medications that can help reduce the symptoms. These include antibiotics, antifungals, and anti-inflammatory medications. In some cases, surgery may be necessary to remove the affected tissue. Additionally, lifestyle changes such as avoiding certain foods and drinks, practicing good oral hygiene, and avoiding smoking can help reduce the symptoms.