Autosomal dominant spastic paraplegia type 73 (SPG73) is a rare, inherited neurological disorder characterized by progressive spasticity (stiffness) and weakness of the legs. It is caused by mutations in the SPG73 gene, which is located on chromosome 17. Symptoms typically begin in childhood or adolescence and worsen over time. Affected individuals may experience difficulty walking, balance problems, and muscle spasms. There is currently no cure for SPG73, but physical therapy and medications may help to manage symptoms.

The symptoms of Autosomal dominant spastic paraplegia type 73 (SPG73) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Abnormal gait
- Urinary and/or fecal incontinence
- Pain in the legs
- Muscle spasms
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal dominant spastic paraplegia type 73 (SPG73) is caused by mutations in the SPG73 gene. This gene is responsible for producing a protein called paraplegin, which is involved in the maintenance of the structure and function of mitochondria. Mutations in this gene can lead to a decrease in the amount of paraplegin produced, resulting in the development of SPG73.

Currently, there is no known cure for Autosomal dominant spastic paraplegia type 73. Treatment focuses on managing the symptoms and preventing further complications. Treatment options may include physical therapy, occupational therapy, speech therapy, medications to reduce muscle spasms, braces or orthotics to support weakened muscles, and surgery to correct any deformities. Additionally, lifestyle modifications such as avoiding activities that may cause further injury, maintaining a healthy diet, and exercising regularly may help to improve symptoms.

1. Family history: Autosomal dominant spastic paraplegia type 73 is an inherited disorder, so having a family history of the condition increases the risk of developing it.

2. Age: The risk of developing Autosomal dominant spastic paraplegia type 73 increases with age.

3. Gender: Autosomal dominant spastic paraplegia type 73 is more common in males than females.

4. Ethnicity: Autosomal dominant spastic paraplegia type 73 is more common in people of Ashkenazi Jewish descent.

At this time, there is no known cure or medications for Autosomal dominant spastic paraplegia type 73. Treatment is focused on managing symptoms and improving quality of life. This may include physical therapy, occupational therapy, speech therapy, and assistive devices.