Autosomal dominant spastic paraplegia type 36 (SPG36) is a rare, inherited neurological disorder characterized by progressive spasticity (stiffness and difficulty with movement) of the lower limbs. It is caused by mutations in the SPG36 gene, which is located on chromosome 17. Symptoms typically begin in childhood or adolescence and may include difficulty walking, weakness in the legs, and spasticity of the lower limbs. Other symptoms may include bladder and bowel dysfunction, muscle wasting, and cognitive impairment. Treatment is supportive and may include physical therapy, medications, and assistive devices.

The symptoms of Autosomal dominant spastic paraplegia type 36 (SPG36) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Abnormal gait
- Urinary and/or fecal incontinence
- Pain in the legs
- Muscle spasms
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal dominant spastic paraplegia type 36 (SPG36) is caused by mutations in the KIF5A gene. This gene provides instructions for making a protein called kinesin-1, which is involved in the transport of materials within cells. Mutations in the KIF5A gene lead to the production of an abnormal kinesin-1 protein, which disrupts the transport of materials within cells and causes the signs and symptoms of SPG36.

1. Physical therapy: Physical therapy can help improve muscle strength, flexibility, and coordination. It can also help reduce spasticity and improve balance and gait.

2. Medications: Medications such as baclofen, diazepam, and tizanidine can help reduce spasticity and improve muscle control.

3. Surgery: Surgery may be recommended in some cases to help improve muscle control and reduce spasticity.

4. Assistive devices: Assistive devices such as braces, walkers, and wheelchairs can help improve mobility and independence.

5. Occupational therapy: Occupational therapy can help improve daily living skills and help with activities of daily living.

1. Family history: Autosomal dominant spastic paraplegia type 36 (SPG36) is caused by a mutation in the SPG36 gene, which is inherited in an autosomal dominant pattern. This means that if one parent has the mutation, there is a 50% chance that their child will inherit the mutation.

2. Age: SPG36 is typically diagnosed in childhood or adolescence, although it can occur at any age.

3. Gender: SPG36 is more common in males than females.

4. Ethnicity: SPG36 is more common in individuals of Ashkenazi Jewish descent.

At this time, there is no known cure for Autosomal dominant spastic paraplegia type 36 (ADSP-36). However, there are medications that can help manage the symptoms of the condition. These include medications to reduce muscle spasms, such as baclofen and diazepam, as well as medications to reduce pain, such as gabapentin and pregabalin. Physical therapy and occupational therapy can also help to improve mobility and reduce pain.