Autosomal dominant spastic paraplegia type 10 (SPG10) is a rare, inherited neurological disorder characterized by progressive spasticity (stiffness) and weakness of the legs. It is caused by mutations in the SPG10 gene, which is located on chromosome 14. Symptoms usually begin in childhood or adolescence and can include difficulty walking, stiffness in the legs, and weakness in the lower limbs. Other symptoms may include bladder and bowel problems, muscle spasms, and difficulty with coordination and balance. There is currently no cure for SPG10, but physical therapy, medications, and assistive devices can help manage symptoms.

The symptoms of Autosomal dominant spastic paraplegia type 10 (SPG10) vary from person to person, but may include:

- Muscle Stiffness and Spasticity in the legs
- Difficulty walking, running, or climbing stairs
- Weakness in the legs
- Loss of sensation in the legs
- Loss of bladder and/or bowel control
- Difficulty with balance and coordination
- Pain in the legs
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal dominant spastic paraplegia type 10 (SPG10) is caused by mutations in the KIF5A gene. This gene provides instructions for making a protein called kinesin family member 5A, which is involved in the transport of materials within cells. Mutations in the KIF5A gene lead to the production of an abnormally short, nonfunctional version of the kinesin family member 5A protein. This protein is unable to transport materials within cells, which disrupts the normal functioning of cells and leads to the signs and symptoms of SPG10.

1. Physical therapy: Physical therapy can help improve muscle strength, flexibility, and coordination. It can also help reduce spasticity and improve balance and gait.

2. Medications: Medications such as baclofen, diazepam, and tizanidine can help reduce spasticity and improve muscle control.

3. Surgery: Surgery may be recommended to release tight muscles or tendons, or to implant a device that can help reduce spasticity.

4. Assistive devices: Assistive devices such as walkers, canes, and wheelchairs can help improve mobility.

5. Occupational therapy: Occupational therapy can help improve daily living skills and help with activities of daily living.

1. Family history: Autosomal dominant spastic paraplegia type 10 (SPG10) is caused by a mutation in the SPG10 gene, which is inherited in an autosomal dominant pattern. This means that if one parent has the mutation, there is a 50% chance that their child will inherit the mutation.

2. Age: SPG10 is typically diagnosed in childhood or adolescence, although it can occur at any age.

3. Gender: SPG10 is more common in males than females.

4. Ethnicity: SPG10 is more common in people of Ashkenazi Jewish descent.

At this time, there is no known cure for Autosomal dominant spastic paraplegia type 10 (ADSP10). However, there are medications that can help manage the symptoms of the condition. These include muscle relaxants, antispasmodic medications, and medications to reduce pain. Physical therapy and occupational therapy can also help improve mobility and reduce pain.