Autosomal dominant severe congenital neutropenia (AD-SCN) is a rare inherited disorder characterized by a deficiency of neutrophils, a type of white blood cell that helps the body fight infection. People with AD-SCN are at an increased risk of recurrent and severe bacterial infections. The disorder is caused by mutations in the ELANE gene, which is responsible for producing the neutrophil elastase enzyme. Treatment typically involves antibiotics and other medications to reduce the risk of infection.

The symptoms of Autosomal dominant severe congenital neutropenia (AD-SCN) vary from person to person, but may include:

-Frequent infections, such as skin, ear, and sinus infections
-Fever
-Swollen lymph nodes
-Fatigue
-Mouth sores
-Gum inflammation
-Poor appetite
-Weight loss
-Diarrhea
-Abdominal pain
-Joint pain
-Rashes
-Bruising or bleeding easily
-Anemia

The exact cause of autosomal dominant severe congenital neutropenia (AD-SCN) is unknown. However, it is believed to be caused by mutations in the ELANE gene, which is responsible for producing the neutrophil elastase enzyme. Mutations in this gene can lead to a decrease in the production of neutrophils, resulting in a decrease in the body's ability to fight off infections.

1. Granulocyte colony-stimulating factor (G-CSF): G-CSF is a medication that stimulates the production of neutrophils, a type of white blood cell. It is used to treat severe neutropenia caused by autosomal dominant severe congenital neutropenia.

2. Antibiotics: Antibiotics are used to treat infections caused by neutropenia.

3. Bone marrow transplant: A bone marrow transplant may be recommended for some people with autosomal dominant severe congenital neutropenia.

4. Immunosuppressive therapy: Immunosuppressive therapy may be used to reduce the body’s immune response and reduce the risk of infection.

5. Splenectomy: A splenectomy is a surgical procedure to remove the spleen. It may be

1. Family history of autosomal dominant severe congenital neutropenia
2. Mutations in the ELANE gene
3. Exposure to certain medications or toxins
4. Certain infections
5. Certain autoimmune disorders
6. Certain genetic disorders

There is no cure for autosomal dominant severe congenital neutropenia (AD-SCN). However, there are medications that can help manage the condition. These include granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). These medications help stimulate the production of neutrophils, which are a type of white blood cell that helps fight infection. Additionally, antibiotics may be prescribed to help prevent and treat infections.