Autosomal dominant secondary polycythemia is a rare genetic disorder that is caused by a mutation in the EPOR gene. This mutation causes the body to produce too many red blood cells, leading to an increased risk of blood clots and other complications. Symptoms of this disorder include headaches, dizziness, fatigue, and shortness of breath. Treatment typically involves medications to reduce the number of red blood cells and to prevent blood clots.

The most common symptoms of Autosomal dominant secondary polycythemia include:

-Headaches

-Dizziness

-Fatigue

-Shortness of breath

-Visual disturbances

-Itching

-Nosebleeds

-High blood pressure

-Enlarged spleen

-Abnormal blood clotting

-Joint pain

-Weight gain

-Abnormal heart rhythms

-Abnormal liver function tests

The exact cause of autosomal dominant secondary polycythemia is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Possible causes include:

-Genetic mutations that affect the production of red blood cells
-Exposure to certain chemicals or toxins
-Certain medications
-Smoking
-Obesity
-Chronic kidney disease
-Chronic lung disease
-Sleep apnea
-High altitude
-Certain types of cancer

1. Phlebotomy: This is a procedure in which a small amount of blood is removed from the body to reduce the number of red blood cells.

2. Hydroxyurea: This is a medication that helps to reduce the production of red blood cells.

3. Interferon-alpha: This is a medication that helps to reduce the production of red blood cells.

4. Anagrelide: This is a medication that helps to reduce the production of red blood cells.

5. Aspirin: This is a medication that helps to reduce the risk of blood clots.

6. Diet and lifestyle changes: Eating a healthy diet and exercising regularly can help to reduce the risk of developing secondary polycythemia.

1. Family history of Autosomal dominant secondary polycythemia
2. Exposure to high altitudes
3. Smoking
4. Chronic lung disease
5. Congenital heart disease
6. Kidney disease
7. Liver disease
8. Certain medications, such as testosterone, anabolic steroids, and erythropoietin
9. Obesity
10. Advanced age

At this time, there is no cure for autosomal dominant secondary polycythemia. Treatment typically involves medications to reduce the production of red blood cells, such as hydroxyurea or anagrelide. Other medications, such as aspirin, may also be prescribed to reduce the risk of blood clots. In some cases, phlebotomy (removal of blood) may be recommended to reduce the number of red blood cells in the body.