Autosomal dominant primary hypomagnesemia with hypocalciuria (ADPH) is a rare inherited disorder characterized by low levels of magnesium in the blood (hypomagnesemia) and low levels of calcium in the urine (hypocalciuria). It is caused by mutations in the TRPM6 gene, which is responsible for the production of a protein that helps regulate magnesium and calcium levels in the body. Symptoms of ADPH can include muscle weakness, fatigue, and seizures. Treatment typically involves dietary changes and supplementation with magnesium and calcium.

The symptoms of Autosomal dominant primary hypomagnesemia with hypocalciuria include:

-Muscle cramps
-Tremors
-Fatigue
-Weakness
-Nausea
-Vomiting
-Loss of appetite
-Abnormal heart rhythms
-Seizures
-Developmental delays
-Behavioral problems
-Growth retardation
-Hypocalcemia (low calcium levels)
-Hypomagnesemia (low magnesium levels)
-Hypercalciuria (high calcium levels in the urine)

The exact cause of Autosomal dominant primary hypomagnesemia with hypocalciuria is unknown. However, it is believed to be caused by mutations in the TRPM6 gene, which is responsible for the production of a protein that helps regulate magnesium and calcium levels in the body. Mutations in this gene can lead to decreased magnesium absorption and increased calcium excretion, resulting in hypomagnesemia and hypocalciuria.

1. Magnesium supplementation: This is the main treatment for Autosomal dominant primary hypomagnesemia with hypocalciuria. Magnesium supplements can be taken orally or intravenously, depending on the severity of the condition.

2. Dietary changes: Increasing dietary intake of magnesium-rich foods such as nuts, legumes, and green leafy vegetables can help to increase magnesium levels in the body.

3. Calcium supplementation: Calcium supplementation may be necessary to prevent hypocalcemia, which can occur as a result of hypomagnesemia.

4. Vitamin D supplementation: Vitamin D supplementation may be necessary to ensure adequate absorption of calcium and magnesium.

5. Medications: Certain medications, such as diuretics, may be prescribed to help reduce the amount of magnesium lost in the urine.

1. Family history of Autosomal dominant primary hypomagnesemia with hypocalciuria
2. Genetic mutations in the TRPM6 gene
3. Low dietary intake of magnesium
4. Certain medications, such as diuretics, proton pump inhibitors, and antacids
5. Chronic kidney disease
6. Certain endocrine disorders, such as hyperparathyroidism and diabetes
7. Certain gastrointestinal disorders, such as Crohn’s disease and celiac disease
8. Certain autoimmune disorders, such as systemic lupus erythematosus and Sjogren’s syndrome

Yes, there is a cure for Autosomal dominant primary hypomagnesemia with hypocalciuria. Treatment typically involves oral magnesium supplementation and dietary modifications to increase magnesium intake. Additionally, medications such as diuretics, calcium channel blockers, and thiazide diuretics may be prescribed to help manage symptoms.