Autosomal dominant optic atrophy, classic form (ADOA-CF) is a rare inherited disorder that affects the optic nerve, which carries visual information from the eye to the brain. It is characterized by progressive vision loss, usually beginning in childhood or adolescence. Symptoms may include decreased visual acuity, color vision deficits, and night blindness. In some cases, the disorder may also cause nystagmus (involuntary eye movements) and strabismus (misalignment of the eyes). ADOA-CF is caused by mutations in the OPA1 gene and is inherited in an autosomal dominant pattern.

The classic form of Autosomal dominant optic Atrophy (ADOA) is characterized by progressive vision loss, usually beginning in childhood. Symptoms may include:

-Decreased visual acuity

-Reduced color vision

-Reduced contrast sensitivity

-Reduced peripheral vision

-Reduced night vision

-Reduced visual field

-Reduced eye movements

-Reduced pupillary reflex

-Abnormal eye movements

-Abnormal eye alignment

-Abnormal eye shape

-Abnormal eye color

-Abnormal eye movements

-Abnormal eye pressure

-Abnormal eye movements

-Abnormal eye movements

-Abnormal eye movements

-Abnormal eye movements

-Abnormal eye movements

-Abnormal eye movements

The classic form of Autosomal dominant optic atrophy (ADOA) is caused by mutations in the OPA1 gene. This gene provides instructions for making a protein that is involved in the structure and function of mitochondria, which are the energy-producing centers in cells. Mutations in the OPA1 gene lead to the production of an abnormal protein that disrupts the structure and function of mitochondria, resulting in the death of cells in the optic nerve and retina.

1. Vitamin E supplementation: Vitamin E supplementation has been shown to improve visual acuity in some patients with Autosomal dominant optic atrophy, classic form.

2. Coenzyme Q10 supplementation: Coenzyme Q10 supplementation has been shown to improve visual acuity in some patients with Autosomal dominant optic atrophy, classic form.

3. Acetazolamide: Acetazolamide is a carbonic anhydrase inhibitor that has been used to improve visual acuity in some patients with Autosomal dominant optic atrophy, classic form.

4. Corticosteroids: Corticosteroids have been used to reduce inflammation and improve visual acuity in some patients with Autosomal dominant optic atrophy, classic form.

5. Surgery: Surgery may be used to correct any structural abnormalities of

1. Family history of Autosomal dominant optic atrophy, classic form
2. Mutations in the OPA1 gene
3. Age (onset typically occurs in childhood or adolescence)
4. Gender (males are more likely to be affected)
5. Ethnicity (more common in people of European descent)

There is no cure for autosomal dominant optic atrophy, classic form. However, there are medications that can help slow the progression of the disease. These medications include vitamin A, vitamin E, and coenzyme Q10. Additionally, some studies have suggested that the antioxidant N-acetylcysteine may be beneficial in slowing the progression of the disease.