Autosomal dominant mitochondrial myopathy with exercise intolerance is a rare genetic disorder that affects the muscles and causes them to become weak and easily fatigued. It is caused by a mutation in the mitochondrial DNA, which is passed down from parent to child in an autosomal dominant pattern. Symptoms typically include muscle weakness, exercise intolerance, and cramping. Other symptoms may include muscle pain, muscle wasting, and difficulty breathing. Treatment typically involves physical therapy, medications, and lifestyle modifications.

The symptoms of Autosomal dominant mitochondrial myopathy with exercise intolerance can vary from person to person, but may include:

- Muscle Weakness and fatigue
- Muscle cramps
- Exercise intolerance
- Difficulty walking
- Difficulty climbing stairs
- Difficulty lifting objects
- Muscle wasting
- Muscle pain
- Difficulty swallowing
- Abnormal heart rate
- Abnormal breathing
- Abnormal blood pressure
- Abnormal blood sugar levels
- Abnormal liver function tests
- Abnormal kidney function tests
- Abnormal vision
- Abnormal hearing
- Abnormal balance
- Abnormal coordination
- Abnormal reflexes
- Abnormal sensation
- Abnormal speech
- Abnormal gait

The exact cause of Autosomal dominant mitochondrial myopathy with exercise intolerance is unknown. However, it is believed to be caused by mutations in the mitochondrial DNA or nuclear DNA that affect the production of proteins involved in energy production in the mitochondria. These mutations can be inherited from a parent or can occur spontaneously.

1. Physical therapy: Physical therapy can help improve muscle strength, flexibility, and endurance.

2. Exercise: Regular exercise can help improve muscle strength and endurance.

3. Diet: Eating a healthy diet can help provide the body with the energy it needs to function properly.

4. Medications: Certain medications can help reduce muscle cramps and spasms, as well as improve muscle strength and endurance.

5. Assistive devices: Assistive devices such as walkers, canes, and wheelchairs can help improve mobility.

6. Surgery: In some cases, surgery may be necessary to correct any structural abnormalities in the muscles or joints.

1. Family history of Autosomal dominant mitochondrial myopathy with exercise intolerance
2. Age of onset (usually between 10 and 20 years old)
3. Genetic mutations in the mitochondrial DNA
4. Prolonged exercise
5. High intensity exercise
6. Poor nutrition
7. Low muscle mass
8. Low muscle strength
9. Poor physical conditioning
10. Heat intolerance

There is no cure for autosomal dominant mitochondrial myopathy with exercise intolerance. However, medications such as Coenzyme Q10, Creatine, and Riboflavin may be used to help manage symptoms. Additionally, physical therapy and lifestyle modifications such as avoiding strenuous exercise and maintaining a healthy diet can help improve quality of life.