Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare, inherited immune disorder characterized by recurrent skin infections, elevated levels of immunoglobulin E (IgE), and other immune system abnormalities. It is caused by mutations in the STAT3 gene. Symptoms may include recurrent skin infections, eczema, recurrent pneumonia, and skeletal abnormalities. Treatment typically involves antibiotics, antifungal medications, and immunosuppressive drugs.

The symptoms of Autosomal dominant hyper-IgE syndrome (AD-HIES) vary from person to person, but may include:

-Recurrent skin infections, such as boils, abscesses, and impetigo
-Recurrent lung infections, such as pneumonia and bronchitis
-Chronic sinusitis
-Recurrent ear infections
-Allergic reactions, such as eczema, asthma, and food allergies
-Recurrent fungal infections, such as oral thrush
-Recurrent viral infections, such as cold sores
-Delayed growth and development
-Frequent fevers
-Enlarged lymph nodes
-Enlarged liver and spleen
-Bone and joint abnormalities
-Cognitive and behavioral problems
-Seizures
-Eye problems, such as catar

Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare genetic disorder caused by mutations in the STAT3 gene. This gene is responsible for producing a protein that helps regulate the body’s immune system. Mutations in this gene can lead to an overproduction of immunoglobulin E (IgE), which can cause recurrent infections, skin rashes, and other symptoms.

1. Antibiotics: Antibiotics are used to treat bacterial infections, which are common in people with Autosomal dominant hyper-IgE syndrome.

2. Immunoglobulin replacement therapy: This therapy replaces the IgE antibodies that are missing in people with Autosomal dominant hyper-IgE syndrome.

3. Anti-inflammatory medications: These medications can help reduce inflammation and swelling in the body.

4. Surgery: Surgery may be necessary to remove abscesses or other infected areas.

5. Allergen avoidance: Avoiding known allergens can help reduce the risk of allergic reactions.

6. Nutritional support: People with Autosomal dominant hyper-IgE syndrome may need to follow a special diet to ensure they get the nutrients they need.

1. Family history: Autosomal dominant hyper-IgE syndrome is an inherited disorder, so having a family history of the condition increases the risk of developing it.

2. Genetic mutations: Mutations in the STAT3 gene are the most common cause of Autosomal dominant hyper-IgE syndrome.

3. Age: Autosomal dominant hyper-IgE syndrome is more common in children and young adults.

Yes, there are medications and treatments available for Autosomal dominant hyper-IgE syndrome. These include antibiotics, anti-inflammatory medications, immunosuppressants, and biologic therapies. Additionally, lifestyle modifications such as avoiding triggers, eating a healthy diet, and getting regular exercise can help manage symptoms.