Autosomal dominant epidermolytic ichthyosis (ADEI) is a rare genetic skin disorder that is characterized by thick, scaly skin. It is caused by a mutation in the keratin gene, which is responsible for the production of proteins that make up the skin's outer layer. Symptoms of ADEI include dry, scaly skin, redness, itching, and blistering. In severe cases, the skin can become thick and leathery. Treatment for ADEI includes topical medications, moisturizers, and light therapy.

The symptoms of Autosomal dominant epidermolytic ichthyosis (ADEI) include:

-Thick, scaly skin that is red and inflamed
-Dry, itchy skin
-Blisters and erosions on the skin
-Thickening of the palms and soles of the feet
-Thickening of the skin on the scalp, face, and neck
-Thickening of the skin around the eyes, nose, and mouth
-Thickening of the skin on the elbows, knees, and other joints
-Thickening of the skin on the palms and soles of the feet
-Thickening of the skin on the back, chest, and abdomen
-Thickening of the skin on the genitals
-Thickening of the skin on the fingers

Autosomal dominant epidermolytic ichthyosis is caused by mutations in the keratin 1 or keratin 10 genes. These genes provide instructions for making proteins that are found in the outer layer of the skin (the epidermis). These proteins form a protective layer that helps keep the skin hydrated and prevents it from becoming dry and cracked. Mutations in either of these genes disrupt the structure and function of the proteins, leading to the formation of thick, scaly patches on the skin.

The main treatment for Autosomal dominant epidermolytic ichthyosis is topical retinoids, such as tazarotene, which can help reduce scaling and improve the appearance of the skin. Other treatments may include topical corticosteroids, moisturizers, and antibiotics to help reduce inflammation and infection. In some cases, systemic retinoids may be prescribed to help reduce the severity of the condition. In severe cases, laser therapy may be used to reduce the appearance of thickened skin.

1. Family history: Autosomal dominant epidermolytic ichthyosis is an inherited condition, so having a family history of the condition increases the risk of developing it.

2. Age: The condition is usually diagnosed in infancy or early childhood.

3. Gender: Males are more likely to be affected than females.

4. Ethnicity: Autosomal dominant epidermolytic ichthyosis is more common in people of Mediterranean, Middle Eastern, and North African descent.

At this time, there is no cure for autosomal dominant epidermolytic ichthyosis. However, there are medications and treatments available to help manage the symptoms. These include topical retinoids, topical corticosteroids, and systemic retinoids. Additionally, moisturizers and emollients can help to reduce the dryness and scaling associated with the condition.