Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation is a rare inherited neurological disorder caused by a mutation in the TFG gene. It is characterized by progressive muscle weakness and wasting in the lower legs and feet, as well as sensory loss in the feet and hands. Symptoms usually begin in childhood or adolescence and worsen over time. Treatment is supportive and may include physical therapy, orthopedic devices, and medications.

The symptoms of Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation can vary from person to person, but generally include:

- Muscle Weakness and wasting in the lower legs and feet
- High arches of the feet
- Hammertoes
- Loss of sensation in the feet and lower legs
- Difficulty walking
- Loss of balance
- Foot drop
- Abnormal gait
- Pain in the feet and lower legs
- Curvature of the spine
- Weakness in the hands and arms
- Loss of sensation in the hands and arms
- Difficulty with fine motor skills
- Loss of reflexes in the lower legs

Charcot-Marie-Tooth disease type 2 due to TFG mutation is caused by a mutation in the TFG gene. This gene provides instructions for making a protein called transgelin, which is involved in the structure and function of nerve cells. Mutations in the TFG gene lead to the production of an abnormal transgelin protein, which disrupts the normal structure and function of nerve cells. This disruption can cause the signs and symptoms of Charcot-Marie-Tooth disease type 2 due to TFG mutation.

1. Physical therapy: Physical therapy can help to improve muscle strength, coordination, and balance. It can also help to reduce pain and improve mobility.

2. Assistive devices: Assistive devices such as braces, canes, and walkers can help to improve mobility and reduce the risk of falls.

3. Medications: Medications such as pain relievers, muscle relaxants, and anticonvulsants can help to reduce pain and improve muscle strength.

4. Surgery: Surgery may be recommended in some cases to correct deformities or to improve mobility.

5. Gene therapy: Gene therapy is a promising new treatment for Charcot-Marie-Tooth disease type 2 due to TFG mutation. It involves introducing a healthy copy of the TFG gene into the body to replace the mutated gene.

1. Family history: Individuals with a family history of Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation are at an increased risk of developing the condition.

2. Age: The risk of developing Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation increases with age.

3. Gender: Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation is more common in males than in females.

4. Ethnicity: Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation is more common in individuals of European descent.

At this time, there is no cure for Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation. However, there are medications and treatments available to help manage the symptoms of the disease. These include medications to reduce pain, physical therapy to help maintain muscle strength and coordination, orthopedic devices such as braces and splints to help with mobility, and surgery to correct foot deformities.