About Aquagenic palmoplantar keratoderma

What is Aquagenic palmoplantar keratoderma?

Aquagenic palmoplantar keratoderma is a rare skin condition characterized by the development of thick, scaly patches on the palms and soles of the feet after contact with water. It is thought to be caused by an abnormal response of the sweat glands to water, resulting in an excessive production of keratin. Symptoms may include itching, burning, and pain. Treatment typically involves the use of topical medications and lifestyle modifications.

What are the symptoms of Aquagenic palmoplantar keratoderma?

The main symptom of Aquagenic palmoplantar keratoderma is the development of thick, scaly patches of skin on the palms and soles of the feet. These patches may be itchy and uncomfortable, and can cause Pain and discomfort when walking. Other symptoms may include:

- Dry, cracked skin

- Blisters or ulcers on the palms and soles

- Thickening of the skin on the palms and soles

- Discoloration of the skin on the palms and soles

- Swelling of the palms and soles

- Painful calluses on the palms and soles

- Increased sensitivity to water

What are the causes of Aquagenic palmoplantar keratoderma?

The exact cause of aquagenic palmoplantar keratoderma is unknown. However, it is believed to be caused by an abnormal response of the skin to water, which leads to an increase in the production of keratin, a protein that makes up the outer layer of the skin. Other possible causes include genetic mutations, environmental factors, and certain medications.

What are the treatments for Aquagenic palmoplantar keratoderma?

The treatments for Aquagenic palmoplantar keratoderma include topical corticosteroids, topical retinoids, systemic retinoids, and phototherapy. In some cases, oral antihistamines may be prescribed to reduce itching. In severe cases, surgery may be necessary to remove thickened skin.

What are the risk factors for Aquagenic palmoplantar keratoderma?

1. Genetic predisposition: Aquagenic palmoplantar keratoderma is believed to be an inherited disorder, although the exact genetic cause is unknown.

2. Exposure to water: Aquagenic palmoplantar keratoderma is triggered by contact with water, and the condition can worsen with increased exposure.

3. Certain medications: Certain medications, such as diuretics, can increase the risk of developing Aquagenic palmoplantar keratoderma.

4. Certain medical conditions: Certain medical conditions, such as diabetes, can increase the risk of developing Aquagenic palmoplantar keratoderma.

Is there a cure/medications for Aquagenic palmoplantar keratoderma?

At this time, there is no known cure for aquagenic palmoplantar keratoderma. However, there are medications that can help to reduce the symptoms. These include topical corticosteroids, topical retinoids, and oral retinoids. Additionally, phototherapy and laser treatments may be used to reduce the appearance of the condition.