Adie Syndrome, also known as Adie's Tonic Pupil, is a neurological disorder that affects the pupil of the eye. It is characterized by a large, sluggish pupil that does not respond to light or accommodation. Other symptoms may include decreased deep tendon reflexes, decreased sweating, and decreased sensation in the affected eye.

The main symptom of Adie Syndrome is an abnormally slow pupil reaction to light (pupillary light reflex). Other symptoms may include:

- Abnormal eye movements (nystagmus)
- Weakness of the eyelid muscles (ptosis)
- Reduced sensitivity to touch (hypoesthesia)
- Reduced sensitivity to vibration (hypoalgesia)
- Reduced deep tendon reflexes
- Muscle weakness
- Impaired coordination
- Difficulty speaking (dysarthria)
- Difficulty swallowing (dysphagia)
- Difficulty walking (ataxia)
- Fatigue

Adie Syndrome is caused by damage to the postganglionic fibers of the parasympathetic nervous system. This damage can be caused by a variety of factors, including viral infections, head trauma, and autoimmune disorders.

The main treatment for Adie Syndrome is to wear corrective lenses to improve vision. Other treatments may include physical therapy to help improve muscle strength and coordination, and medications to help reduce muscle spasms. Surgery may be recommended in some cases to help improve vision.

1. Viral infections
2. Trauma to the eye
3. Autoimmune disorders
4. Diabetes
5. Multiple sclerosis
6. Lyme disease
7. Sarcoidosis
8. Systemic lupus erythematosus
9. Hypothyroidism
10. Vitamin B12 deficiency

There is no cure for Adie Syndrome, but medications such as anticholinergics, sympathomimetics, and botulinum toxin injections may be used to help manage the symptoms.